Mapping Ventricular Changes Related to Dementia and Mild Cognitive Impairment in a Large Community-Based Cohort
Abstract
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance (MR) image scan. The technique combines a robust, automated technique for ventricular segmentation with a 3D surface-based radial thickness mapping approach that allows spatially-localized statistical tests of relative shape differences between clinical groups. The technique is used to analyze localized ventricular expansion in Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large cohort of community-dwelling elderly individuals (N=339). The resulting maps are the first to chart localized ventricular dilation in a cohort of this size. Besides showing patterns of ventricular expansion that may be consistent with the spatial progression of AD-related pathology, the maps reveal new information about localized ventricular atrophy that may have been overlooked to date. A detailed understanding of spatial atrophy patterns may be useful for early disease detection or for patient monitoring in drug trials.
BibTeX
@conference{Carmichael-2006-9437,author = {Owen Carmichael and P. M. Thompson and R. A. Dutton and A. Lu and S. E. Lee and J. Y. Lee and L. H. Kuller and Oscar Lopez and Howard Aizenstein and C. C. Meltzer and Yanxi Liu and A. W. Toga and Jim Becker},
title = {Mapping Ventricular Changes Related to Dementia and Mild Cognitive Impairment in a Large Community-Based Cohort},
booktitle = {Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano (ISBI '06)},
year = {2006},
month = {April},
pages = {315 - 318},
}